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Substanzprofil
Psilocybin ist ein natürlich vorkommendes Tryptamin-Derivat, das in über 200 Pilzarten der Gattung Psilocybe gefunden wird. Nach oraler Einnahme wird es durch alkalische Phosphatasen rasch zu Psilocin dephosphoryliert, welches als eigentlicher Wirkstoff die Blut-Hirn-Schranke überwindet. Psilocin wirkt primär als Agonist am serotonergen 5-HT2A-Rezeptor und löst tiefgreifende Veränderungen der Wahrnehmung, des Denkens und des emotionalen Erlebens aus. In klinischen Studien zeigt Psilocybin vielversprechende Ergebnisse bei der Behandlung von therapieresistenter Depression, Suchterkrankungen und existenzieller Angst bei terminalen Erkrankungen.
Primary mechanism of psychedelic action via cortical serotonin receptor activation
Decreases connectivity in the DMN, facilitating novel cognitive patterns
Promotes dendritic spine growth and synaptogenesis via BDNF/TrkB signaling
Berichtete subjektive Effekte basierend auf klinischen und Community-Daten
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression
Psilocybin: Chemical Foundations and Emerging Therapeutic Potential.
[Perspectives opened up by the physiopathological understanding of psychiatric disorders].
[Pharmacological post-acute treatment of alcohol use disorder: Established strategies and innovative approaches].
Psilocybin-assisted therapy for major depressive disorder: Perspective from meta-analysis.
Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions.
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial.
Psychedelics and Mental Health in Endurance Athletes: A Cross-Sectional Study in Brazil.
Psychological support in psychedelic-assisted therapy clinical trials: A systematic review.
Pharmacological regulation of adult brain neuroplasticity: Synergistic roles of neuropeptide signaling, psychedelics, and synaptic modulators.
Psilocybin effects on brain functional connectivity: a systematic review of fMRI studies.
Differential Effects of Acute and Chronic Fluoxetine on Psychedelic-Induced Behavior in Mice: Implications for Clinical Trials.
Cost-Effectiveness of Psilocybin-Assisted Therapy Versus Standard of Care for Patients With Treatment-Resistant Depression.
Strategic Neurodelivery of Psychedelic Compounds: Bridging Molecular Pharmacology with Therapeutic Innovation in CNS Disorders.
Psychedelics for treatment of negative symptoms and depressive symptoms in schizophrenia spectrum disorder: A narrative review.
Psychedelic therapy and cultural humility.
A randomized clinical trial of repeated doses of psilocybin for the treatment of obsessive-compulsive disorder.
Digital Intervention for Psychedelic Preparation (DIPP): protocol for a randomised controlled feasibility trial comparing meditation- and music-based programmes in healthy volunteers.
Psilocybin or Nicotine Patch for Smoking Cessation: A Pilot Randomized Clinical Trial.
Hope for Neurotic Disorders: A Summary of New Zealand Research on the Development of Biomarkers and Novel Treatments.
Trends in first-time psychedelic and other hallucinogen use in the United States: Results from the National Survey on Drug Use and Health.
Psilocybin and Ibogaine in Cocaine-Seeking: Extinction Enhancement Without Relapse Prevention.
Efficacy and risks of psychedelics in treatment of posttraumatic stress disorder: A systematic review.
The Use of Psilocybin in the Treatment of Depressive Disorders: A Narrative Review.
A Promise Without Panacea: Psychedelic-Assisted Therapies in Modern Psychiatry.
Psychedelics and the Extracellular Matrix: Rewiring Neuroplasticity and Metaplasticity for Next-Generation Psychiatric Therapies.
Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review.
Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSD
Advancing cancer neuroscience through stress modulation: Interdisciplinary potential of psilocybin and ketamine.
Safety Profile of Psilocybin for Cocaine Use Disorder
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks.
Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter
RCT of Psilocybin-assisted CBT for Depression
Psilocybin to Treat Depression in Spinal Cord Injury
Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility Study
Effects of psychedelic microdosing on cognitive functions: A systematic review and meta-analysis.
Psilocybin Microdosing With Psychotherapy for Treatment-Resistant Depression
Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community.
The transformational power of psychedelics: catalysts for creativity, consciousness, and mental health.
Emerging mechanisms of psilocybin-induced neuroplasticity.
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
Psilocybin-Assisted Psychotherapy in Cancer Patients With Adjustment Disorder
The therapeutic potential of psilocybin beyond psychedelia through shared mechanisms with ketamine.
Between enhancement and risk: A critical review of psychedelic microdosing.
Psilocybin-assisted psychotherapy for depression and anxiety associated with life threatening illness: A phase 2b randomized controlled trial.
PRoMiSS: Psilocybin and the Role of Music in Set and Setting
Psychedelic-Assisted Therapy: Potential Benefits and Challenges in Mental Health Treatment.
Use of Psychedelic Agents in Older Adults with Treatment-Resistant Major Depressive Disorder: What the Evidence Shows.
Control Group Outcomes in Trials of Psilocybin, SSRIs, or Esketamine for Depression: A Meta-Analysis.