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> Evidence for psilocybin in treatment-resistant depression
Bottom Line
Strong evidence from 3 RCTs and 2 meta-analyses supports psilocybin-assisted therapy for treatment-resistant depression, with response rates of 50-70% at 3 weeks. GRADE: Moderate. Larger Phase III trials are underway.
3
RCTs
2
Meta-Analyses
436
Participants
COMP360 psilocybin therapy for treatment-resistant depression
Goodwin et al. 2022 · N Engl J Med · n=233
Trial of psilocybin versus escitalopram for depression
Carhart-Harris et al. 2021 · N Engl J Med · n=59
Efficacy of psilocybin for depressive disorders: a systematic review
Galvao-Coelho et al. 2023 · J Psychopharmacol
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