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Substanzprofil
Ketamin ist ein dissoziatives Anästhetikum und nicht-kompetitiver NMDA-Rezeptor-Antagonist mit einzigartiger schnell einsetzender antidepressiver Wirkung. Seit den 1960er-Jahren als Narkosemittel zugelassen, hat es in den letzten zwei Jahrzehnten eine Renaissance als Antidepressivum erfahren. Subanästhetische Dosen erzeugen eine dissoziative Erfahrung und stimulieren die synaptische Plastizität über AMPA-Rezeptor-Potenzierung und mTOR-Signalwege. Esketamin (Spravato) ist seit 2019 für therapieresistente Depression zugelassen und stellt den ersten grundlegend neuen Wirkmechanismus in der Depressionsbehandlung seit Jahrzehnten dar.
Non-competitive blockade producing dissociation
Glutamate burst → AMPA → BDNF/mTOR cascade within hours
Disrupts depressive rumination patterns
Berichtete subjektive Effekte basierend auf klinischen und Community-Daten
Ketamine and Midazolam Infusions for CRPS: Feasibility Study
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
Ketamine HCl Prolonged Release Oral Tablets for CRPS
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Esketamine and postoperative cognitive dysfunction in aged mice: Role of the SIRT3/AMPK/mTOR pathway.
[Recognising and treating depression - a practical overview of current treatment algorithms and evidence-based recommendations].
Successful Emergency Removal of a Titanium Penile Constriction Ring Using Blood Aspiration and Nonpowered Bolt Cutters.
Impact of subanesthetic ketamine delivered via AmyloLipid nanovesicle (ALN)-based intranasal system on biobehavioral responses in an animal model of PTSD.
[Perspectives opened up by the physiopathological understanding of psychiatric disorders].
Esketamine-Based Opioid-Free versus Opioid-Based Anesthesia for Recovery Quality After Laparoscopic Transabdominal Preperitoneal Repair: A Randomized Noninferiority Trial.
Ultrasound-guided transversus abdominis plane block in cesarean delivery: a randomized trial of ketamine versus neostigmine as bupivacaine adjuvants.
Pharmacotherapy in Disorders of Consciousness: A Mechanism-Based Review.
Cognitive Effects of Esketamine in Treatment-Resistant Depression: A Systematic Review.
Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach.
NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine.
Ketamine Use for ED Sedation: Pharmacologic Basis, Clinical Applications, and Safety Considerations.
Comparative analysis of esketamine versus remimazolam in adult and pediatric surgical patients: a multimodal monitoring evaluation.
Preoperative Anxiety and Postoperative Delirium: A Mini Review of the Association, Mechanisms, and Preventive Strategies.
Single low-dose esketamine improves postpartum depression symptoms and recovery quality in cesarean section women.
Esketamine nasal spray for treatment-resistant depression: A retrospective multicenter real-world cohort study on effectiveness and suicidal outcomes.
Opioid-Free Versus Opioid-Based Anesthesia for Quality of Recovery Following Laparoscopic Hysterectomy: A Randomized Controlled Non-Inferiority Trial.
Comparison of the Effective Dose 90 (ED90) and Clinical Outcomes of Fentanyl Versus Esketamine for Analgesia in Hysteroscopy: A Two-Part, Randomized, Double-Blind Trial.
Esketamine hydrochloride in the management of moderate-to-severe depressive symptoms in patients undergoing multiple wound repair surgeries: A multi-centre randomized, double-blind, placebo-controlled trial.
Effect of Remimazolam or Propofol Combined With Esketamine on Anesthesia and Early Perioperative Neurocognitive Disorders in Patients Undergoing Thoracoscopic Partial Lung Resection: A Randomized Clinical Trial.
The Montreal model of ketamine-therapy for alcohol use disorder and comorbid treatment-resistant depression: protocol for a feasibility trial.
Pharmacological regulation of adult brain neuroplasticity: Synergistic roles of neuropeptide signaling, psychedelics, and synaptic modulators.
Esketamine-based PCIA combined with intercostal nerve block for acute pain after lobectomy: a randomized controlled trial.
Ketamine as an NMDA-modulating therapy in bipolar disorder: rationale and evidence.
Neuroprotective role of Bougainvillea spectabilis in ketamine-induced neurotoxicity: targeting oxidative stress and neuroinflammation.
Role of Anesthesia in ECT for Major Depressive Disorder.
Long-term relief of CRPS-associated limb dystonia with ketamine infusion.
[Consumer wearables, cardiology and clinical practice].
Disruption of psychostimulant-associated memories by single, low dose ketamine in rats.
Prehospital management of acute behavioural disturbance: managing severe agitation in the prehospital setting - a systematic literature review.
Cannabidiol Mitigates Ketamine-Induced Hyperlocomotion via Allosteric Potentiation of Ventral Tegmental GlyRα1 Signaling.
First report of malignant hyperthermia syndrome in an American Guinea hog.
Intranasal esketamine: real-world clinical practice in treatment-resistant depression and factors associated with treatment response.
Comment on Esketamine 5 Years After Approval: Welcome New Data With Continuing Questions.
A Blueprint for Implementing Ketamine-Assisted Psychotherapy in Palliative Care: Design, Process, and Treatment Patterns of a Real-World Clinical Program.
Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke-depression comorbidity.
Comparative EEG analysis of the effects of ketamine enantiomers and metabolites in rhesus macaques.
Predisposing Factors for Chronic Post-Surgical Pain After Thoracic Surgery: A Scoping Review with Quantitative Synthesis.
Commentary on "Long-term treatment with esketamine nasal spray in patients with treatment resistant depression: Results from the ESCAPE-LTE study".
Blood biomarker changes and relationships after low dose oral ketamine treatment for post-traumatic stress disorder (PTSD).
Decoding the molecular network communication mechanism of ketamine's antidepressant effects.
Mental health professionals' perspective on the use of esketamine in treatment-resistant depression and their motivation to adopt it: a Saudi cross-sectional study.
Evaluation of Current Evidence on the Efficacy of Esketamine in Treating Substance-Use Disorders in Patients With Treatment-Resistant Depression (TRD): A Narrative Review.
Providing feedback to frontline paramedics involved in research: a service evaluation within Yorkshire Ambulance Service.
Differential effects of ketamine enantiomers on EEG parameters including the gamma-delta shift phenomenon.
Ketamine pharmacotherapy for major depressive disorder: A narrative review.