Erhalten Sie eine woechentliche Zusammenfassung der neuesten psychedelischen Forschung, neuer Studien und Plattform-Updates direkt in Ihren Posteingang.
Kein Spam, nie. Jederzeit abbestellbar.
Substanzprofil
Ketamin ist ein dissoziatives Anästhetikum und nicht-kompetitiver NMDA-Rezeptor-Antagonist mit einzigartiger schnell einsetzender antidepressiver Wirkung. Seit den 1960er-Jahren als Narkosemittel zugelassen, hat es in den letzten zwei Jahrzehnten eine Renaissance als Antidepressivum erfahren. Subanästhetische Dosen erzeugen eine dissoziative Erfahrung und stimulieren die synaptische Plastizität über AMPA-Rezeptor-Potenzierung und mTOR-Signalwege. Esketamin (Spravato) ist seit 2019 für therapieresistente Depression zugelassen und stellt den ersten grundlegend neuen Wirkmechanismus in der Depressionsbehandlung seit Jahrzehnten dar.
Non-competitive blockade producing dissociation
Glutamate burst → AMPA → BDNF/mTOR cascade within hours
Disrupts depressive rumination patterns
Berichtete subjektive Effekte basierend auf klinischen und Community-Daten
Ketamine and Midazolam Infusions for CRPS: Feasibility Study
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
Ketamine HCl Prolonged Release Oral Tablets for CRPS
Examining Analgesic Synergy and Efficacy in Trauma Care
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delivery Under Spinal Anesthesia
Kappa-Opioid Receptor Antagonism Prolongs the Antidepressant Effects of Ketamine in Adult Mice with Depression-like Behavior Induced by Adolescent Chronic Unpredictable Stress.
Biological Risk Factors for Suicidal Behavior in Children and Adolescents: A Narrative Review.
Neuroimaging insights from Wistar-Kyoto rats under chronic mild stress: morphological and metabolic brain correlates of treatment-resistant depression.
Ketamine as a Rapid-Acting Antidepressant: A Scoping Review of Mechanisms and Efficacy in Treatment-Resistant Depression.
Astaxanthin as a Therapeutic Candidate for Nociceptive and Inflammatory Pain: Mechanisms and Perspectives.
Efficacy and Safety of Intranasal Esketamine in Treatment-Resistant Depression with Comorbid Autism Spectrum Disorder: Three Case Reports.
Ketamine for depression - a critical perspective.
Oral Ketamine for Chronic Pain: Towards an Evidence-Based Dosing Regimen.
When the therapist hallucinates: AI, psychedelics, and the risks of unsupervised digital mental health care.
[Esketamine alleviates depression-like behaviors in mice with chronic restraint stress by activating glutamatergic neurons in the medial prefrontal cortex].
Comparative Effectiveness of Single-Dose Epidural Esketamine versus Hydromorphone in Thoracic and Upper Abdominal Surgery: A Randomized Trial.
Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids.
Ultrasound-guided transversus abdominis plane block in cesarean delivery: a randomized trial of ketamine versus neostigmine as bupivacaine adjuvants.
Pharmacotherapy in Disorders of Consciousness: A Mechanism-Based Review.
Esketamine-Based Opioid-Free versus Opioid-Based Anesthesia for Recovery Quality After Laparoscopic Transabdominal Preperitoneal Repair: A Randomized Noninferiority Trial.
Successful Emergency Removal of a Titanium Penile Constriction Ring Using Blood Aspiration and Nonpowered Bolt Cutters.
Impact of subanesthetic ketamine delivered via AmyloLipid nanovesicle (ALN)-based intranasal system on biobehavioral responses in an animal model of PTSD.
[Perspectives opened up by the physiopathological understanding of psychiatric disorders].
Esketamine and postoperative cognitive dysfunction in aged mice: Role of the SIRT3/AMPK/mTOR pathway.
[Recognising and treating depression - a practical overview of current treatment algorithms and evidence-based recommendations].
N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine.
Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach.
NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine.
Cognitive Effects of Esketamine in Treatment-Resistant Depression: A Systematic Review.
Preoperative Anxiety and Postoperative Delirium: A Mini Review of the Association, Mechanisms, and Preventive Strategies.
Comparative analysis of esketamine versus remimazolam in adult and pediatric surgical patients: a multimodal monitoring evaluation.
Single low-dose esketamine improves postpartum depression symptoms and recovery quality in cesarean section women.
Ketamine Use for ED Sedation: Pharmacologic Basis, Clinical Applications, and Safety Considerations.
Esketamine nasal spray for treatment-resistant depression: A retrospective multicenter real-world cohort study on effectiveness and suicidal outcomes.
Opioid-Free Versus Opioid-Based Anesthesia for Quality of Recovery Following Laparoscopic Hysterectomy: A Randomized Controlled Non-Inferiority Trial.
Effect of Remimazolam or Propofol Combined With Esketamine on Anesthesia and Early Perioperative Neurocognitive Disorders in Patients Undergoing Thoracoscopic Partial Lung Resection: A Randomized Clinical Trial.
Esketamine-based PCIA combined with intercostal nerve block for acute pain after lobectomy: a randomized controlled trial.
Comparison of the Effective Dose 90 (ED90) and Clinical Outcomes of Fentanyl Versus Esketamine for Analgesia in Hysteroscopy: A Two-Part, Randomized, Double-Blind Trial.
The Montreal model of ketamine-therapy for alcohol use disorder and comorbid treatment-resistant depression: protocol for a feasibility trial.
Ketamine as an NMDA-modulating therapy in bipolar disorder: rationale and evidence.
Pharmacological regulation of adult brain neuroplasticity: Synergistic roles of neuropeptide signaling, psychedelics, and synaptic modulators.
Esketamine hydrochloride in the management of moderate-to-severe depressive symptoms in patients undergoing multiple wound repair surgeries: A multi-centre randomized, double-blind, placebo-controlled trial.
[Consumer wearables, cardiology and clinical practice].
Long-term relief of CRPS-associated limb dystonia with ketamine infusion.
Neuroprotective role of Bougainvillea spectabilis in ketamine-induced neurotoxicity: targeting oxidative stress and neuroinflammation.
Role of Anesthesia in ECT for Major Depressive Disorder.
First report of malignant hyperthermia syndrome in an American Guinea hog.
Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke-depression comorbidity.
Die wichtigsten Fragen zu Ketamine