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Substanzprofil
N,N-Dimethyltryptamin (DMT) ist ein natürlich vorkommendes Tryptamin, das in zahlreichen Pflanzen und Tieren vorkommt und als eines der potentesten kurzwirksamen Psychedelika gilt. Als Rauchform erzeugt es innerhalb von Sekunden eine intensive, aber kurze psychedelische Erfahrung von 15-30 Minuten. In der traditionellen Ayahuasca-Zubereitung wird DMT mit einem MAO-Hemmer (typischerweise Banisteriopsis caapi) kombiniert, was die orale Bioverfügbarkeit ermöglicht und die Wirkdauer auf 4-6 Stunden verlängert. Die Forschung untersucht DMT und Ayahuasca bei Depression, Suchterkrankungen und posttraumatischen Belastungsstörungen.
Rapid-onset serotonin 2A activation producing intense visual phenomena
Modulates calcium signaling and cellular stress response
Harmine/harmaline inhibit MAO-A enabling oral DMT bioavailability
Berichtete subjektive Effekte basierend auf klinischen und Community-Daten
Disease Activity Following Cessation of Dimethyl Fumarate in Patients with Relapsing-Remitting Multiple Sclerosis.
Psilocybin: Chemical Foundations and Emerging Therapeutic Potential.
Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial.
Streamlining Eligibility Assessment for Alzheimer's Disease-Modifying Therapies: Prediction of MMSE Scores Using the Digital Clock and Recall.
Beyond the toad's kiss: Mapping acute 5-MeO-DMT effects on brain connectivity across sex and dose using awake rat neuroimaging.
Managing Relapsing Multiple Sclerosis Across the Lifespan: A Narrative Review with Expert Opinion from Norway.
Psychedelics and Mental Health in Endurance Athletes: A Cross-Sectional Study in Brazil.
International Expert Opinion on Optimal Switching to Cladribine Tablets from Other High-Efficacy Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: Opportunities and Challenges.
Strategic Neurodelivery of Psychedelic Compounds: Bridging Molecular Pharmacology with Therapeutic Innovation in CNS Disorders.
LGBTQ+ Ayahuasca Retreat Experience is Associated with Benefits to Mental Health, Quality of Life, and Spiritual Well-Being: A Prospective, Naturalistic Study.
Determinants of change in disease-modifying drugs in patients with multiple sclerosis: A registry-based study.
Analysis of herpes zoster cases in multiple sclerosis patients treated with disease-modifying drugs: insights from the EudraVigilance database.
The predictive value of serum neurofilament light chain in achieving no evidence of disease activity-3 (NEDA-3) status in treatment-naïve patients with multiple sclerosis.
Effects of disease modifying therapy on cognitive proficiency in pediatric-onset multiple sclerosis (POMS).
Association of cytokine levels with treatment duration and patient family history in Egyptian multiple sclerosis patients.
Predicting drug-drug interactions between ayahuasca alkaloids and SSRIs using physiologically based pharmacokinetic modeling.
Positioning siponimod and the post-treatment gap: the unmet needs of SPMS patients in Italian real-world practice.
Challenging The Diagnosis of Multiple Sclerosis: Histopathological Insights Gained Through Brain Biopsies.
Clinical Outcomes of Autologous Hematopoietic Stem Cell Transplantation in Filipino Patients With Multiple Sclerosis: A Single-Center Retrospective Case Series.
Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review.
Psychedelics and the Extracellular Matrix: Rewiring Neuroplasticity and Metaplasticity for Next-Generation Psychiatric Therapies.
5-HT2A receptors in the prelimbic cortex VIP-expressing interneurons: A mechanism for psychedelic-induced innate fear attenuation.
A phase 2 uncontrolled, open-label study of intranasal BPL-003 (5-methoxy-N,N-dimethyltryptamine) in patients with treatment-resistant depression.
Safety of breastfeeding under monoclonal antibodies in the offspring of mothers with multiple sclerosis or neuromyelitis optica spectrum disorder.
Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community.
The transformational power of psychedelics: catalysts for creativity, consciousness, and mental health.
Safety and tolerability of multiple sublingual microdoses of 5-MeO-DMT in adults with moderate symptoms of depression and/or anxiety: a randomized, double-blind, placebo-controlled study.
Use of Psychedelic Agents in Older Adults with Treatment-Resistant Major Depressive Disorder: What the Evidence Shows.
Safety, tolerability and subjective effects of vaporized N,N-Dimethyltryptamine: A randomized double-blind clinical trial.
Safety and tolerability of NN-dimethyltryptamine (DMT) in healthy volunteers and Major Depressive Disorder (MDD) patients: A systematic review of early-phase clinical trials.
Serotonergic psychedelics for depression: A comprehensive overview.
Clinical pharmacology.
Human neuroimaging: fMRI.
Evidence that 5-HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non-psychedelic drugs.
Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives.
Psychedelics, entactogens and psychoplastogens for depression and related disorders.
Immunomodulatory and behavioral effects of ayahuasca and N, N-dimethyltryptamine in a rat model of lipopolysaccharide-induced depression.
The effect of psychedelic microdosing on animal behavior: A review with recommendations for the field.
Ayahuasca-inspired DMT/HAR formulation reduces brain differentiation between self and other faces.
Psychedelics for Cancer Pain and Associated Psychological Distress: A Narrative Review of a Potential Strategy.
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression.
Rapid and sustained antidepressant effects of vaporized N,N-dimethyltryptamine: a phase 2a clinical trial in treatment-resistant depression.
Ayahuasca: pharmacology, safety, and therapeutic effects.
Is there a place for psychedelics in sports practice?
Neuroplasticity and psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models.
Psychedelics in neuroinflammation: Mechanisms and therapeutic potential.
Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies.
Psychedelic-assisted treatment for substance use disorder: A narrative systematic review.
Scoping Review: The Role of Psychedelics in the Management of Chronic Pain.
The immunomodulatory effects of classical psychedelics: A systematic review of preclinical studies.