Studien-Browser

Diese Machbarkeitsstudie untersucht die Sicherheit und Praktikabilität einer fünftägigen ambulanten Infusionsbehandlung mit Ketamin plus Midazolam oder Midazolam allein bei Erwachsenen mit komplexem r...

Antimuscarinic delirium (AMD) is a common and dangerous toxicology condition caused by poisoning by medications and other chemicals that block muscarinic receptors. Physostigmine, the standard antidot...

Originalsprache: Englisch

Until recently, acute ischemic stroke (AIS) patients with a baseline large infarct core have been generally excluded from clinical trials of endovascular therapy (EVT). A first multicenter randomized...

Originalsprache: Englisch

This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patie...

Originalsprache: Englisch

Diese klinische Studie untersucht die Wirksamkeit von vernebelt verabreichtem Ketamin als Zusatztherapie zur Standardbehandlung bei mittelschweren bis schweren Asthmaanfällen in der Notaufnahme. In ei...

This study will examine the safety and efficacy of the O'Neil Long Acting Naltrexone Implant (OLANI) in persons with opioid dependency who are seeking relapse-prevention treatment. All participants wi...

Originalsprache: Englisch

Diese Studie untersucht die Wirksamkeit von Ketamin-HCl-Retardtabletten bei Patienten mit komplexem regionalem Schmerzsyndrom (CRPS). Neben der Schmerzlinderung werden auch die Durchführbarkeit des St...

Diese Studie untersucht, ob eine einzelne Gabe von Psilozybin die interozeptive Bewusstseinswahrnehmung (Körperempfindungen) bei chronischen Rückenschmerzpatienten in physikalischer Therapie verbesser...

Ketamine has disputed effects on suicidal ideation scores in depressed populations. This study assessed effectiveness of ketamine in adults with treatment resistant depression, examining a secondary o...

Originalsprache: Englisch

Major depressive disorder (MDD) is a leading cause of disability worldwide, and currently available antidepressants remain limited by delayed onset of action, incomplete response, and adverse effects....

Originalsprache: Englisch

Ketamine triggers cellular pyroptosis through an NOD-like receptor protein 3 (NLRP3)/caspase-1 pathway, leading to neurotoxicity and cognitive deficits. Dopamine receptor D1 (DRD1) activation, however...

Originalsprache: Englisch

Sepsis remains a critical global healthcare challenge, with a high mortality rate of 30.8% among critical illnesses, second only to cancer. Currently, there is a lack of effective clinical treatments....

Originalsprache: Englisch

Ketamine, including its enantiomers (S)-ketamine (esketamine) and (R)-ketamine (arketamine), has demonstrated rapid antidepressant effects in major depressive disorder (MDD) and bipolar disorder (BD),...

Originalsprache: Englisch

The clinical trial NCT03866252 investigates the antidepressant effects of lysergic acid diethylamide (LSD) in 61 patients with major depressive disorder (MDD) randomized to low-dose LSD (LD-LSD; 2 &#x...

Originalsprache: Englisch

Interest in ayahuasca and its main component, N,N-Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragment...

Originalsprache: Englisch

Aldehyde dehydrogenase 2 (ALDH2) serves an important role in regulating the development of organ injury. The present study aimed to investigate the effects of ALDH2 gene expression on the oxidative st...

Originalsprache: Englisch

Intravenous (IV) low-dose ketamine has emerged as a promising treatment for patients with treatment-resistant depression (TRD). However, its impact on cognitive functioning remains unclear. This syste...

Originalsprache: Englisch

Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic-assisted therapy, using substances such...

Originalsprache: Englisch

The aim of this study was to investigate the influence of troxerutin on ketamine-induced schizophrenia-like behaviors in male mice, as well as its effects on antioxidant levels in brain tissue and ser...

Originalsprache: Englisch

Lysosomal storage diseases (LSDs) are rare genetic disorders treated with enzyme replacement therapy (ERT). However, treatment outcomes are highly variable, reflecting the complexities of therapeutic...

Originalsprache: Englisch