Sicherheits-Datenbank

Umfassende Sicherheitsinformationen für psychedelische Substanzen

Diese Informationen dienen ausschliesslich Bildungs- und Harm-Reduction-Zwecken. Sie stellen keine medizinische Beratung dar. Konsultieren Sie immer qualifiziertes medizinisches Fachpersonal vor jeder Substanzeinnahme. Im Notfall rufen Sie sofort die Notrufnummer an.

Nebenwirkungen

Kritische Ereignisse

Schwere Ereignisse

Notfallprotokolle

Nach Substanz filtern

QT Prolongation

Ibogaine

critical

Häufigkeit30-50%

Dauer: 12-24 hours

Behandlung: ECG monitoring mandatory, cardiac screening pre-treatment

Cardiac Arrest (rare)

Ibogaine

critical

Häufigkeit<1%

Dauer: acute

Behandlung: Emergency cardiac care, pre-screening essential

Psychotic Break (rare)

LSD

critical

Häufigkeit<0.5%

Dauer: hours-days

Behandlung: Emergency psychiatric care, benzodiazepines first-line (avoid antipsychotics initially), safe environment, continuous monitoring

Serotonin Syndrome Risk

DMT / Ayahuasca

critical

Häufigkeitdose-dependent

Dauer: acute

Behandlung: CRITICAL with concurrent SSRIs/MAOIs. Stop all serotonergic drugs. Cyproheptadine 12mg PO, cooling measures, emergency services

MAOI-Drug Interactions

DMT / Ayahuasca

critical

Häufigkeitvaries

Dauer: varies

Behandlung: Ayahuasca contains MAOIs — screen ALL medications. Contraindicated with SSRIs, SNRIs, tramadol, DXM, stimulants, tyramine-rich food

Respiratory Depression/Apnea

5-MeO-DMT

critical

Häufigkeit10-20%

Dauer: 1-5 minutes

Behandlung: CRITICAL: Maintain airway, recovery position, pulse oximetry mandatory, supplemental O2 available, trained sitter essential

Hyponatremia

MDMA

severe

Häufigkeit<5%

Dauer: acute

Behandlung: Emergency medical care, restrict water intake

Suicidal Ideation (post)

MDMA

severe

Häufigkeit2-5%

Dauer: days

Behandlung: Psychological support, safety planning, monitoring

Urinary Tract Damage

Ketamine

severe

Häufigkeitrare (chronic use)

Dauer: chronic

Behandlung: Limit frequency, urological monitoring

Extreme Panic/Terror

5-MeO-DMT

severe

Häufigkeit15-30%

Dauer: 5-30 minutes

Behandlung: Cannot be aborted once inhaled; trained sitter must provide physical safety; benzodiazepine post-peak if needed

Psychological Destabilization

5-MeO-DMT

severe

Häufigkeit5-10%

Dauer: days-weeks

Behandlung: Integration therapy essential; may trigger depersonalization/derealization; psychiatric follow-up if persistent

Challenging Psychological Experience

Psilocybin

moderate-severe

Häufigkeit10-20%

Dauer: 1-6 hours

Behandlung: Trained therapist support, grounding techniques

Hyperthermia

MDMA

moderate-severe

Häufigkeit10-20%

Dauer: 2-4 hours

Behandlung: Cool environment, hydration (not excess), monitoring

HPPD (Hallucinogen Persisting Perception Disorder)

LSD

moderate-severe

Häufigkeit1-5%

Dauer: weeks-years

Behandlung: Avoid further psychedelic use, benzodiazepines for acute episodes, clonidine may help; refer to psychiatrist

Intense Fear/Panic

DMT / Ayahuasca

moderate-severe

Häufigkeit20-35%

Dauer: 1-4 hours

Behandlung: Trained sitter support, grounding techniques, reassurance; reminder that experience is temporary and substance-induced

Reactivations (Spontaneous Re-experiencing)

5-MeO-DMT

moderate-severe

Häufigkeit5-15%

Dauer: days-weeks post

Behandlung: Normalize as part of integration process; grounding techniques; therapy referral; avoid additional psychedelics

Anxiety/Panic

Psilocybin

moderate

Häufigkeit20-30%

Dauer: 1-4 hours

Behandlung: Reassurance, calm environment, benzodiazepines if severe

HPPD (rare)

Psilocybin

moderate

Häufigkeit<1%

Dauer: weeks-months

Behandlung: Benzodiazepines, avoid further psychedelic use

Elevated Blood Pressure

Ketamine

moderate

Häufigkeit30-50%

Dauer: 30-60 min

Behandlung: Monitor, contraindicated in uncontrolled hypertension

Dependence Potential

Ketamine

moderate

Häufigkeit5-15% (repeated use)

Dauer: chronic

Behandlung: Limit treatment frequency, screening

Ataxia

Ibogaine

moderate

Häufigkeit80-100%

Dauer: 24-72 hours

Behandlung: Bed rest, supervision

Anxiety/Panic Reaction

LSD

moderate

Häufigkeit15-25%

Dauer: 2-6 hours

Behandlung: Reassurance, calm environment, grounding techniques; benzodiazepines if severe (diazepam 5-10mg PO)

Thought Loops / Cognitive Distortion

LSD

moderate

Häufigkeit20-40%

Dauer: 2-6 hours

Behandlung: Change setting, music, or physical position; gentle verbal redirect; benzodiazepine if distressing

Hypertension

DMT / Ayahuasca

moderate

Häufigkeit20-40%

Dauer: 2-4 hours

Behandlung: BP monitoring; sublingual nifedipine if systolic >180; reduce stimulation; contraindicated in uncontrolled hypertension

Cardiovascular Stress

DMT / Ayahuasca

moderate

Häufigkeit15-30%

Dauer: 2-4 hours

Behandlung: Cardiac screening pre-ceremony; continuous pulse monitoring; contraindicated in cardiovascular disease

Cardiovascular Stimulation

5-MeO-DMT

moderate

Häufigkeit30-50%

Dauer: 15-45 minutes

Behandlung: BP and HR monitoring throughout; contraindicated in cardiovascular disease and uncontrolled hypertension

Severe Nausea/Vomiting

Mescaline

moderate

Häufigkeit50-70%

Dauer: 1-3 hours

Behandlung: Common during onset; ginger, lying down, small sips of water; ondansetron 4mg if severe; fasting beforehand reduces severity

Anxiety/Dysphoria

Mescaline

moderate

Häufigkeit15-25%

Dauer: 2-6 hours

Behandlung: Grounding techniques, change of setting, calm reassurance; benzodiazepine if escalating

Serotonin Depletion (post)

MDMA

mild-moderate

Häufigkeit30-50%

Dauer: 1-5 days

Behandlung: Rest, nutrition, 5-HTP (24h+ after), time

Dissociation

Ketamine

mild-moderate

Häufigkeit50-80%

Dauer: 30-90 min

Behandlung: Expected effect, safe environment

Vasoconstriction (peripheral)

LSD

mild-moderate

Häufigkeit20-40%

Dauer: 6-12 hours

Behandlung: Warm blankets, magnesium supplement, avoid additional vasoconstrictors; monitor extremities

Purging (Vomiting/Diarrhea)

DMT / Ayahuasca

mild-moderate

Häufigkeit60-80%

Dauer: 1-3 hours

Behandlung: Considered normal in ceremonial context; provide buckets, water, electrolyte replacement; monitor for dehydration

Vasoconstriction

Mescaline

mild-moderate

Häufigkeit20-35%

Dauer: 4-8 hours

Behandlung: Warm environment, magnesium supplement, avoid additional vasoconstrictors; monitor extremities for color changes

Tachycardia

Mescaline

mild-moderate

Häufigkeit25-40%

Dauer: 4-8 hours

Behandlung: Monitor heart rate; usually self-resolving; contraindicated in cardiac arrhythmias; beta-blockers if persistent

Nausea/Vomiting

Psilocybin

mild

Häufigkeit15-25%

Dauer: 30-60 min

Behandlung: Ginger tea, lying down, small sips of water

Headache

Psilocybin

mild

Häufigkeit10-20%

Dauer: 4-24 hours

Behandlung: Standard analgesics (not NSAIDs during session)

Elevated Blood Pressure

Psilocybin

mild

Häufigkeit10-15%

Dauer: 2-4 hours

Behandlung: Monitor, usually self-resolving

Bruxism/Jaw Clenching

MDMA

mild

Häufigkeit60-80%

Dauer: 3-6 hours

Behandlung: Magnesium supplement, chewing gum

Nausea/Vomiting

Ketamine

mild

Häufigkeit20-40%

Dauer: 30-60 min

Behandlung: Ondansetron pretreatment, fasting

Insomnia

LSD

mild

Häufigkeit60-80%

Dauer: 12-24 hours

Behandlung: Expected due to 8-12h duration; dose in morning, melatonin or low-dose benzodiazepine for sleep if needed

Sicherheits-Datenbank

Umfassende Sicherheitsinformationen für psychedelische Substanzen

Nebenwirkungen

Kritische Ereignisse

Schwere Ereignisse

Notfallprotokolle

Nach Substanz filtern

QT Prolongation

Ibogaine

critical

Häufigkeit30-50%

Dauer: 12-24 hours

Behandlung: ECG monitoring mandatory, cardiac screening pre-treatment

Cardiac Arrest (rare)

Ibogaine

critical

Häufigkeit<1%

Dauer: acute

Behandlung: Emergency cardiac care, pre-screening essential

Psychotic Break (rare)

LSD

critical

Häufigkeit<0.5%

Dauer: hours-days

Behandlung: Emergency psychiatric care, benzodiazepines first-line (avoid antipsychotics initially), safe environment, continuous monitoring

Serotonin Syndrome Risk

DMT / Ayahuasca

critical

Häufigkeitdose-dependent

Dauer: acute

Behandlung: CRITICAL with concurrent SSRIs/MAOIs. Stop all serotonergic drugs. Cyproheptadine 12mg PO, cooling measures, emergency services

MAOI-Drug Interactions

DMT / Ayahuasca

critical

Häufigkeitvaries

Dauer: varies

Behandlung: Ayahuasca contains MAOIs — screen ALL medications. Contraindicated with SSRIs, SNRIs, tramadol, DXM, stimulants, tyramine-rich food

Respiratory Depression/Apnea

5-MeO-DMT

critical

Häufigkeit10-20%

Dauer: 1-5 minutes

Behandlung: CRITICAL: Maintain airway, recovery position, pulse oximetry mandatory, supplemental O2 available, trained sitter essential

Hyponatremia

MDMA

severe

Häufigkeit<5%

Dauer: acute

Behandlung: Emergency medical care, restrict water intake

Suicidal Ideation (post)

MDMA

severe

Häufigkeit2-5%

Dauer: days

Behandlung: Psychological support, safety planning, monitoring

Urinary Tract Damage

Ketamine

severe

Häufigkeitrare (chronic use)

Dauer: chronic

Behandlung: Limit frequency, urological monitoring

Extreme Panic/Terror

5-MeO-DMT

severe

Häufigkeit15-30%

Dauer: 5-30 minutes

Behandlung: Cannot be aborted once inhaled; trained sitter must provide physical safety; benzodiazepine post-peak if needed

Psychological Destabilization

5-MeO-DMT

severe

Häufigkeit5-10%

Dauer: days-weeks

Behandlung: Integration therapy essential; may trigger depersonalization/derealization; psychiatric follow-up if persistent

Challenging Psychological Experience

Psilocybin

moderate-severe

Häufigkeit10-20%

Dauer: 1-6 hours

Behandlung: Trained therapist support, grounding techniques

Hyperthermia

MDMA

moderate-severe

Häufigkeit10-20%

Dauer: 2-4 hours

Behandlung: Cool environment, hydration (not excess), monitoring

HPPD (Hallucinogen Persisting Perception Disorder)

LSD

moderate-severe

Häufigkeit1-5%

Dauer: weeks-years

Behandlung: Avoid further psychedelic use, benzodiazepines for acute episodes, clonidine may help; refer to psychiatrist

Intense Fear/Panic

DMT / Ayahuasca

moderate-severe

Häufigkeit20-35%

Dauer: 1-4 hours

Behandlung: Trained sitter support, grounding techniques, reassurance; reminder that experience is temporary and substance-induced

Reactivations (Spontaneous Re-experiencing)

5-MeO-DMT

moderate-severe

Häufigkeit5-15%

Dauer: days-weeks post

Behandlung: Normalize as part of integration process; grounding techniques; therapy referral; avoid additional psychedelics

Anxiety/Panic

Psilocybin

moderate

Häufigkeit20-30%

Dauer: 1-4 hours

Behandlung: Reassurance, calm environment, benzodiazepines if severe

HPPD (rare)

Psilocybin

moderate

Häufigkeit<1%

Dauer: weeks-months

Behandlung: Benzodiazepines, avoid further psychedelic use

Elevated Blood Pressure

Ketamine

moderate

Häufigkeit30-50%

Dauer: 30-60 min

Behandlung: Monitor, contraindicated in uncontrolled hypertension

Dependence Potential

Ketamine

moderate

Häufigkeit5-15% (repeated use)

Dauer: chronic

Behandlung: Limit treatment frequency, screening

Ataxia

Ibogaine

moderate

Häufigkeit80-100%

Dauer: 24-72 hours

Behandlung: Bed rest, supervision

Anxiety/Panic Reaction

LSD

moderate

Häufigkeit15-25%

Dauer: 2-6 hours

Behandlung: Reassurance, calm environment, grounding techniques; benzodiazepines if severe (diazepam 5-10mg PO)

Thought Loops / Cognitive Distortion

LSD

moderate

Häufigkeit20-40%

Dauer: 2-6 hours

Behandlung: Change setting, music, or physical position; gentle verbal redirect; benzodiazepine if distressing

Hypertension

DMT / Ayahuasca

moderate

Häufigkeit20-40%

Dauer: 2-4 hours

Behandlung: BP monitoring; sublingual nifedipine if systolic >180; reduce stimulation; contraindicated in uncontrolled hypertension

Cardiovascular Stress

DMT / Ayahuasca

moderate

Häufigkeit15-30%

Dauer: 2-4 hours

Behandlung: Cardiac screening pre-ceremony; continuous pulse monitoring; contraindicated in cardiovascular disease

Cardiovascular Stimulation

5-MeO-DMT

moderate

Häufigkeit30-50%

Dauer: 15-45 minutes

Behandlung: BP and HR monitoring throughout; contraindicated in cardiovascular disease and uncontrolled hypertension

Severe Nausea/Vomiting

Mescaline

moderate

Häufigkeit50-70%

Dauer: 1-3 hours

Behandlung: Common during onset; ginger, lying down, small sips of water; ondansetron 4mg if severe; fasting beforehand reduces severity

Anxiety/Dysphoria

Mescaline

moderate

Häufigkeit15-25%

Dauer: 2-6 hours

Behandlung: Grounding techniques, change of setting, calm reassurance; benzodiazepine if escalating

Serotonin Depletion (post)

MDMA

mild-moderate

Häufigkeit30-50%

Dauer: 1-5 days

Behandlung: Rest, nutrition, 5-HTP (24h+ after), time

Dissociation

Ketamine

mild-moderate

Häufigkeit50-80%

Dauer: 30-90 min

Behandlung: Expected effect, safe environment

Vasoconstriction (peripheral)

LSD

mild-moderate

Häufigkeit20-40%

Dauer: 6-12 hours

Behandlung: Warm blankets, magnesium supplement, avoid additional vasoconstrictors; monitor extremities

Purging (Vomiting/Diarrhea)

DMT / Ayahuasca

mild-moderate

Häufigkeit60-80%

Dauer: 1-3 hours

Behandlung: Considered normal in ceremonial context; provide buckets, water, electrolyte replacement; monitor for dehydration

Vasoconstriction

Mescaline

mild-moderate

Häufigkeit20-35%

Dauer: 4-8 hours

Behandlung: Warm environment, magnesium supplement, avoid additional vasoconstrictors; monitor extremities for color changes

Tachycardia

Mescaline

mild-moderate

Häufigkeit25-40%

Dauer: 4-8 hours

Behandlung: Monitor heart rate; usually self-resolving; contraindicated in cardiac arrhythmias; beta-blockers if persistent

Nausea/Vomiting

Psilocybin

mild

Häufigkeit15-25%

Dauer: 30-60 min

Behandlung: Ginger tea, lying down, small sips of water

Headache

Psilocybin

mild

Häufigkeit10-20%

Dauer: 4-24 hours

Behandlung: Standard analgesics (not NSAIDs during session)

Elevated Blood Pressure

Psilocybin

mild

Häufigkeit10-15%

Dauer: 2-4 hours

Behandlung: Monitor, usually self-resolving

Bruxism/Jaw Clenching

MDMA

mild

Häufigkeit60-80%

Dauer: 3-6 hours

Behandlung: Magnesium supplement, chewing gum

Nausea/Vomiting

Ketamine

mild

Häufigkeit20-40%

Dauer: 30-60 min

Behandlung: Ondansetron pretreatment, fasting

Insomnia

LSD

mild

Häufigkeit60-80%

Dauer: 12-24 hours

Behandlung: Expected due to 8-12h duration; dose in morning, melatonin or low-dose benzodiazepine for sleep if needed

Sicherheits-Datenbank

QT Prolongation

Cardiac Arrest (rare)

Psychotic Break (rare)

Serotonin Syndrome Risk

MAOI-Drug Interactions

Respiratory Depression/Apnea

Hyponatremia

Suicidal Ideation (post)

Urinary Tract Damage

Extreme Panic/Terror

Psychological Destabilization

Challenging Psychological Experience

Hyperthermia

HPPD (Hallucinogen Persisting Perception Disorder)

Intense Fear/Panic

Reactivations (Spontaneous Re-experiencing)

Anxiety/Panic

HPPD (rare)

Elevated Blood Pressure

Dependence Potential

Ataxia

Anxiety/Panic Reaction

Thought Loops / Cognitive Distortion

Hypertension

Cardiovascular Stress

Cardiovascular Stimulation

Severe Nausea/Vomiting

Anxiety/Dysphoria

Serotonin Depletion (post)

Dissociation

Vasoconstriction (peripheral)

Purging (Vomiting/Diarrhea)

Vasoconstriction

Tachycardia

Nausea/Vomiting

Headache

Elevated Blood Pressure

Bruxism/Jaw Clenching

Nausea/Vomiting

Insomnia

Auf dem Laufenden bleiben

Sicherheits-Datenbank

QT Prolongation

Cardiac Arrest (rare)

Psychotic Break (rare)

Serotonin Syndrome Risk

MAOI-Drug Interactions

Respiratory Depression/Apnea

Hyponatremia

Suicidal Ideation (post)

Urinary Tract Damage

Extreme Panic/Terror

Psychological Destabilization

Challenging Psychological Experience

Hyperthermia

HPPD (Hallucinogen Persisting Perception Disorder)

Intense Fear/Panic

Reactivations (Spontaneous Re-experiencing)

Anxiety/Panic

HPPD (rare)

Elevated Blood Pressure

Dependence Potential

Ataxia

Anxiety/Panic Reaction

Thought Loops / Cognitive Distortion

Hypertension

Cardiovascular Stress

Cardiovascular Stimulation

Severe Nausea/Vomiting

Anxiety/Dysphoria

Serotonin Depletion (post)

Dissociation

Vasoconstriction (peripheral)

Purging (Vomiting/Diarrhea)

Vasoconstriction

Tachycardia

Nausea/Vomiting

Headache

Elevated Blood Pressure