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Sub-perceptual doses over weeks or months following a fixed schedule (Fadiman or Stamets protocol).
Microdosing refers to the regular intake of sub-perceptual doses of psychedelics -- typically 1/10 to 1/20 of a full dose. Two main protocols: (1) Fadiman Protocol -- 1 day dose, 2 days off, over 4-8 weeks. (2) Stamets Stack -- 4 days dose (combined with lion's mane and niacin), 3 days off, over 4 weeks.
Sub-threshold 5-HT2A agonism. Proposed neuroplasticity enhancement without perceptual disruption. Evidence for mechanism remains inconclusive.