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Traditional and neo-shamanic ceremonies with psychoactive plants in a ritual framework.
Indigenous healing traditions with psychoactive plants have a millennia-long history. Modern Western adaptations often combine traditional elements with Western therapeutic frameworks. Clinical evidence is limited to observational studies and case series, but shows promising signals.
Varies by substance. Ayahuasca: DMT 5-HT2A agonism + MAO inhibition. 5-MeO-DMT: potent 5-HT1A/2A agonism. Ibogaine: multi-receptor (kappa opioid, NMDA, sigma-2).