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Substance Profile
Salvinorin A is the psychoactive diterpenoid from Salvia divinorum. It is unique as the only known non-alkaloid psychedelic and acts selectively at the kappa-opioid receptor (KOR) without affinity for the 5-HT2A receptor.
Reported subjective effects based on clinical and community data
The translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies.
Antinociceptive effect of salvinorin A from the extract of Salvia divinorum in formalin-evoked trigeminal pain behavior in mice: Underlying mechanisms.
Emerging Psychotropic Drug for the Treatment of Trigeminal Pain: Salvinorin A.
Salvinorin A ameliorates pilocarpine-induced seizures by regulating hippocampal microglia polarization.
The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depressive-like Behaviors.
DARK Classics in Chemical Neuroscience: Salvinorin A.
Alleviation of Cocaine Withdrawal and Pertinent Interactions between Salvinorin-Based Antagonists and Kappa Opioid Receptor.
Solving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor.
Age-related changes in peripheral nociceptor function.
6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects.
The Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salvinorin-A.
Salvia divinorum increases alcohol intake and tonic immobility whilst decreasing food intake in Wistar rats.
Chemical syntheses of the salvinorin chemotype of KOR agonist.
Molecular Interaction Between Butorphanol and κ-Opioid Receptor.
Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action.
Antinociceptive effects of Salvia divinorum and bioactive salvinorins in experimental pain models in mice.
A review of salvinorin analogs and their kappa-opioid receptor activity.
Neuropathic and inflammatory antinociceptive effects and electrocortical changes produced by Salvia divinorum in rats.
Salvia divinorum: An overview of the usage, misuse, and addiction processes.
Kappa Opioids, Salvinorin A and Major Depressive Disorder.
Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET.
Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders.
Salvinorin a and related compounds as therapeutic drugs for psychostimulant-related disorders.
Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism.
Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues.
Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse.
From local to global-fifty years of research on Salvia divinorum.
Learning and memory impairment induced by salvinorin A, the principal ingredient of Salvia divinorum, in wistar rats.
Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum.
Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.
Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors.
The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice.
Opioid receptors and legal highs: Salvia divinorum and Kratom.
Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward.
The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats.
Salvia divinorum and salvinorin A: an update on pharmacology and analytical methodology.
Salvinorin A: from natural product to human therapeutics.
Hallucinatory and rewarding effect of salvinorin A in zebrafish: kappa-opioid and CB1-cannabinoid receptor involvement.
Pattern of use and subjective effects of Salvia divinorum among recreational users
The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea-pig ileum.
Psychopharmacology of the hallucinogenic sage Salvia divinorum.
Salvinorin A: a novel and highly selective kappa-opioid receptor agonist.
Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.