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Substance Profile
Psilocin (4-HO-DMT) is the active metabolite of psilocybin. After oral ingestion, psilocybin is converted to psilocin through dephosphorylation, which crosses the blood-brain barrier and mediates the psychedelic effects as a primary 5-HT2A agonist.
Reported subjective effects based on clinical and community data
Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons.
Serotonergic modulation of cortical gamma synchronization: right-lateralized psilocin effects on 40 Hz auditory steady-state responses in rats.
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Structure-based discovery of nonhallucinogenic psychedelic analogs
Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study in Healthy Subjects
Broadband Cortical Desynchronization Underlies the Human Psychedelic State