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Substance Profile
Harmaline is a beta-carboline alkaloid and the dihydrogenated analog of harmine. Found in Banisteriopsis caapi and Peganum harmala, it is a potent reversible MAO-A inhibitor with stronger activity than harmine. Harmaline possesses intrinsic psychoactive properties, producing dream-like visionary states at higher doses. In ayahuasca preparations, it works alongside harmine and THH as the MAO inhibitor enabling oral activity of DMT.
Reported subjective effects based on clinical and community data
The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro
Personality, Psychopathology, Life Attitudes and Neuropsychological Performance among Ritual Users of Ayahuasca: A Longitudinal Study
Psychedelic 5-Methoxy-N,N-Dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions
The Olivocerebellar Projection Mediates Ibogaine-Induced Degeneration of Purkinje Cells: A Model of Indirect, Trans-Synaptic Excitotoxicity