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Substance Profile
DOI (2,5-dimethoxy-4-iodoamphetamine) is a potent psychedelic amphetamine and one of the most widely used pharmacological tools in 5-HT2A receptor research. As a radioiodinated compound ([125I]DOI), it serves globally as the standard radioligand for serotonin receptor mapping. The psychedelic effects last 16-24 hours. DOI shows potent anti-inflammatory effects in preclinical studies through 5-HT2A-mediated signaling pathways.
No subjective effects data available yet.
Fentanyl, Methamphetamine and Polysubstance Use Differentially Affect Locomotor Sensitisation and Social Behaviour in Rats: Psychedelic Treatment Reverses Social Deficits.
Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI.
Distinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI.
Psychedelics as anti-inflammatory agents