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Substance Profile
Aeruginascin is a quaternary ammonium tryptamine found in Inocybe aeruginascens and some Psilocybe species. It is the trimethyl analog of psilocybin (trimethylated at nitrogen rather than dimethylated). Aeruginascin has been proposed as a potential explanation for the characteristically pleasant, non-anxious nature of I. aeruginascens intoxications, possibly by acting as a 5-HT3 antagonist that modulates the serotonergic tone of the psilocybin experience. It may also contribute to the 'entourage effect' in whole-mushroom preparations. Its exact pharmacological role remains an active research question.
Proposed mechanism; may modulate serotonergic tone and reduce anxiety component of psilocybin experience
Possible synergistic interaction with psilocybin at 5-HT2A receptors
No subjective effects data available yet.
No linked studies yet.