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Substance Profile
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent tryptamine found naturally in various plants (Anadenanthera peregrina) and in the skin secretion of the Sonoran Desert toad (Incilius alvarius). It differs pharmacologically from N,N-DMT through its high affinity for the 5-HT1A receptor, producing a qualitatively different experience often described as 'non-dual'. The effects are extremely intense but brief (20-45 minutes when inhaled). Clinical studies are investigating 5-MeO-DMT as a rapid-acting therapeutic for depression and anxiety disorders.
High-affinity 5-HT1A distinguishes from other tryptamines
Most potent ego-dissolution agent; complete self-boundary loss
Reported subjective effects based on clinical and community data
Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial.
Beyond the toad's kiss: Mapping acute 5-MeO-DMT effects on brain connectivity across sex and dose using awake rat neuroimaging.
Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community.
Safety and tolerability of multiple sublingual microdoses of 5-MeO-DMT in adults with moderate symptoms of depression and/or anxiety: a randomized, double-blind, placebo-controlled study.
Clinical pharmacology.
Serotonergic psychedelics for depression: A comprehensive overview.
Evidence that 5-HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non-psychedelic drugs.
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression.
The immunomodulatory effects of classical psychedelics: A systematic review of preclinical studies.
Efficacy of Sublingual 5-MeO-DMT for Reducing Anxiety and Depression in MCI
Adverse Events in Studies of Classic Psychedelics: A Systematic Review and Meta-Analysis.
Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents.
Psychedelics: From Cave Art to 21st-Century Medicine for Addiction.
Traditional Medicine, Culture, and Psychedelic Science: New Pathways for Recovery From Substance Use Disorders.
Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile.
Orally Active Forms of DMT, 5-MeO-DMT, and Long-Acting MDMA for the Treatment of Neuropsychiatric Disorders.
Set and setting predict psychopathology, wellbeing and meaningfulness of psychedelic experiences: a correlational study.
Psychedelics for treatment resistant depression: are they game changers?
The clinical pharmacology and potential therapeutic applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT).
A narrative synthesis of research with 5-MeO-DMT.
Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders.