The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity

ObservationalManualJanuary 10, 2014DOI

Abstract

The MTLs appear to be specifically implicated in the mechanism of action of MDMA, but further work is required to elucidate how the drug's characteristic subjective effects arise from its modulation of spontaneous brain activity.

Authors (23)

LeadCentre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London. Electronic address: r.carhart-harris@imperial.ac.uk

Cardiff University

Brain (Germany)

Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London

Institute of Neurobiology

University College London

Centre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London

Ineke De MeerImanova (MBW, IDM, MT, RDN), Centre for Imaging Sciences, London

Mark TannerImanova (MBW, IDM, MT, RDN), Centre for Imaging Sciences, London

Robin J. TyackeCentre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London

Kim WolffKing's College London

Arjun SethiCentre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London

Michael BloomfieldImperial College London

Tom A. WilliamsCentre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London

Mark BolstridgeCentre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London

Lorna StewartUniversity College London

Celia J. A. MorganUniversity College London

Rexford D. NewbouldImanova (MBW, IDM, MT, RDN), Centre for Imaging Sciences, London

Amanda FeildingBeckley Foundation

HV CurranUniversity College London

David NuttCentre for Neuropsychopharmacology (RLC-H, DE, LTJW, LR, SB, RT, AS, TMW, MB, DJN) and C3NL (RL), Division of Brain Sciences, Faculty of Medicine, London, London

MeSH Terms

MDMAEuphoriantCerebral blood flowPsychologyAmygdalaResting state fMRINeuroscienceHippocampusHallucinogenPutamenFunctional magnetic resonance imagingAnesthesiaInternal medicineMedicinePsychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorForensic Toxicology and Drug Analysis

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Metadata

Study TypeObservational

SourceManual

Publication DateJanuary 10, 2014

Citations182

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