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Affects 30-50% of patients with advanced cancer or terminal illness. Existential distress, death anxiety, and demoralization significantly reduce quality of life in the final months.
Palliative psychiatry: SSRIs/SNRIs, benzodiazepines, meaning-centered psychotherapy, dignity therapy. Treatment options are limited and often have slow onset relative to prognosis.
Psilocybin-assisted therapy has produced some of the most compelling results in all of psychedelic research. A single high-dose session can produce rapid, sustained reductions in anxiety and depression that persist for months. Many participants report a profound shift in their relationship with mortality.
Griffiths et al. (2016): 80% showed clinically significant decreases in depression/anxiety at 6 months. Ross et al. (2016): Single psilocybin dose produced rapid, sustained anti-anxiety effects in cancer patients.